Differential effects of clonidine, haloperidol, diazepam and tryptophan depletion on focused attention and attentional search

@article{Coull1995DifferentialEO,
  title={Differential effects of clonidine, haloperidol, diazepam and tryptophan depletion on focused attention and attentional search},
  author={Jennifer T. Coull and Barbara J. Sahakian and Helen. middleton and Allan Hunter Young and S. B. G. Park and Rupert H McShane and Philip J. Cowen and Trevor W. Robbins},
  journal={Psychopharmacology},
  year={1995},
  volume={121},
  pages={222-230}
}
As the catecholamines have long been implicated in attentional processes, the present investigation compared the effects of the mixedα 1/α 2 adrenoceptor agonist clonidine (CLO), the benzodiazepine diazepam (DZP), the D1/D2 antagonist haloperidol (HAL) and a low-tryptophan drink (Lo-TRP) on performance of tests of selective attention with distractors in four groups of young, healthy volunteers. Using a placebo-controlled, cross-over design, selective and dissociable effects on performance were… CONTINUE READING
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