Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations.

@article{Yamamoto1994DifferentialEO,
  title={Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations.},
  author={Bryan K. Yamamoto and Michael Cooperman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1994},
  volume={14 7},
  pages={4159-66}
}
Typical and atypical antipsychotic drugs have been reported to affect basal dopaminergic activity differentially in nigrostriatal and limbic structures after acute and chronic administration in animals. In addition, glutamate has been implicated in the pathophysiology of schizophrenia. The purpose of this study was to examine basal and locally stimulated glutamate and dopamine efflux in the caudate, nucleus accumbens, and medial prefrontal cortex using in vivo microdialysis after chronic… CONTINUE READING