Differential effects of carbamazepine and lithium on sensitization and kindling

  title={Differential effects of carbamazepine and lithium on sensitization and kindling},
  author={Robert M. Post and Susan R B Weiss and Agu Pert},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • R. PostS. WeissA. Pert
  • Published 31 December 1984
  • Psychology, Biology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry

Carbamazepine in the Treatment of Cocaine-Induced Disorders

Contrary to expectations, carbamazepine was highly effective in blocking the development of both lidocaine-and cocaine-kindled seizures.

The behavioral actions of lithium in rodent models: Leads to develop novel therapeutics

Dopaminergic effects of carbamazepine. Relationship to clinical response in affective illness.

Assessment of the dopamine metabolite homovanillic acid in the cerebrospinal fluid of affectively ill patients provides further evidence that carbamazepine does not have a biochemical profile typical of neuroleptics.

Protective effects of lithium chloride on seizure susceptibility: Involvement of α2-adrenoceptor

Carbamazepine Effects on Afterdischarge, Memory Retrieval, and Conditioned Avoidance Response Latency in Hippocampally Kindled Cats

Caramazepine effects on complex partial seizures and afterdischarges, memory retrieval, and conditioned avoidance response (CAR) latencies were studied in a group of 9 hippocampally kindled cats.



Kindling and Carbamazepine in Affective Illness

Kindling represents a process in which increasing behavioral and convulsive responses occur to repetition of the same stimulus over time. Increased behavioral response can also occur to repetition of

Cocaine, kindling, and psychosis.

A kindling model for psychological stimuli that combines neurophysiological, biochemical, and psychological perspectives is suggested and reviewed, supporting a pharmacological kindling mechansim.

Biochemical effects of carbamazepine: Relationship to its mechanisms of action in affective illness

Interchangeability of stress and amphetamine in sensitization.

It is suggested that amphetamine and at least some stressors may be interchangeable in their ability to induce a sensitization, and the possibility that stress might be a common variable contributing to both amphetamine psychosis and some forms of schizophrenia is raised.

Progressive Changes in Behavior and Seizures Following Chronic Cocaine Administration: Relationship to Kindling and Psychosis

The effects of repetitive cocaine administration on a variety of neurological, behavioral, and biochemical parameters are focused on and the mechanisms involved in the transition from predominantly affective symptoms to those in the schizophreniform spectrum with chronic stimulant administration are presented.

Prophylactic effects of phenytoin, phenobarbital, and carbamazepine examined in kindling cat preparations.

The kindling preparation appears to possess many desirable features as an ideal model of human epilepsy for the purpose of assessment and recruitment of potential antiepileptic drugs and development of a rational pharmacotherapeutic approach for the management and prevention of seizure disorder.

Pharmacological prophylaxis in the kindling model of epilepsy.

  • J. Wada
  • Biology, Psychology
    Archives of neurology
  • 1977
It is envisaged that judicious use of the kindling preparation might also enable us to gain some insight into the mechanisms by which drugs produce their prophylactic or therapeutic effect.

Development of a New Pharmacological Seizure Model: Effects of Anticonvulsants on Cortical‐and Amygdala‐Kindled Seizures in the Rat

It is concluded that the kindling preparation could provide new pharmacological models for several different types of clinical seizure, likely to be as a model for complex partial seizures, since there is at present no satisfactory pharmacological model for these common and drug‐resistant attacks.