Differential effects of azelnidipine and amlodipine on sympathetic nerve activity in patients with primary hypertension.

@article{Inomata2014DifferentialEO,
  title={Differential effects of azelnidipine and amlodipine on sympathetic nerve activity in patients with primary hypertension.},
  author={Jun-ichiro Inomata and Hisayoshi Murai and Shuichi Kaneko and Takuto Hamaoka and Tatsunori Ikeda and Daisuke Kobayashi and Soichiro Usui and Hiroshi Furusho and Yu Sugiyama and Shigeo Takata and Masayuki Takamura},
  journal={Journal of hypertension},
  year={2014},
  volume={32 9},
  pages={1898-904}
}
OBJECTIVE Calcium channel blockers (CCBs) are used as antihypertensive agents and have a strong vasodilatory effect; however, the sympathetic activation mediated by baroreflex might cause adverse effects. A recently developed CCB, azelnidipine, decreases the heart rate (HR) while lowering blood pressure (BP), possibly by inhibiting sympathetic nerve activity in animal models. In this study, we evaluated whether azelnidipine inhibited sympathetic nerve activity, compared to amlodipine, in… CONTINUE READING

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