Differential effects of antiepileptic drugs on neonatal outcomes.

  title={Differential effects of antiepileptic drugs on neonatal outcomes.},
  author={Page B. Pennell and Ana Maria Klein and Nancy Browning and Gus Baker and Jill Clayton-Smith and Laura A. Kalayjian and Joyce D Liporace and Marco Privitera and Tamara Crawford and David W. Loring and Kimford J. Meador},
  journal={Epilepsy & behavior : E&B},
  volume={24 4},
Offspring of women with epilepsy (WWE) on AEDs are at increased risks for major congenital malformations and reduced cognition. They may be at risk for other adverse neonatal outcomes. Women with epilepsy on carbamazepine (CBZ), lamotrigine (LTG), phenytoin (PHT), or valproate (VPA) monotherapy were enrolled in a prospective, observational, multicenter study of the neurodevelopmental effects of AEDs. The odds ratio for small for gestational age (SGA) was higher for VPA vs. PHT, VPA vs. LTG, and… CONTINUE READING
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