Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons.

@article{Park2014DifferentialEO,
  title={Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons.},
  author={Sung Woo Park and Jung Goo Lee and Mi Kyoung Seo and Chan Hong Lee and Hye Yeon Cho and Bong Ju Lee and Wongi Seol and Young Hoon Kim},
  journal={The international journal of neuropsychopharmacology},
  year={2014},
  volume={17 11},
  pages={1831-46}
}
Recent studies suggest that ketamine produces antidepressant actions via stimulation of mammalian target of rapamycin (mTOR), leading to increased levels of synaptic proteins in the prefrontal cortex. Thus, mTOR activation may be related to antidepressant action. However, the mTOR signalling underlying antidepressant drug action has not been well investigated. The aim of the present study was to determine whether alterations in mTOR signalling were observed following treatment with… CONTINUE READING
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