Differential effects of angiotensin II receptor blockade on pressure-induced left ventricular hypertrophy and fibrosis in rats.

Abstract

The effects of the angiotensin II receptor type 1 (AT1) antagonist losartan on pressure overload-induced left ventricular (LV) hypertrophy were studied in female Sprague-Dawley rats. Starting on the day of surgery, losartan (L, 12 mg/kg/day) was administered as continuous intraperitoneal infusion for 2 weeks by using alzet mini-osmotic-pumps (model 2002… (More)

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@article{Baba1999DifferentialEO, title={Differential effects of angiotensin II receptor blockade on pressure-induced left ventricular hypertrophy and fibrosis in rats.}, author={Hideo Baba and Takehisa Iwai and M. Bauer and Michael J. Irlbeck and Karl J. Schmid and Heiko Zimmer}, journal={Journal of molecular and cellular cardiology}, year={1999}, volume={31 2}, pages={445-55} }