Differential effects of aneugens and clastogens on incidences of multinucleated cells and of micronucleate cells in Chinese hamster lung (V79) cell line in vitro.


Two aneugens, vinblastine (0.025-0.4 microgram/ml) and colchicine (0.05-0.4 microgram/ml), and two clastogens, mitomycin C (0.05-0.4 microgram/ml) and cyclophosphamide (1-16 micrograms/ml) were applied respectively to the micronucleus test in Chinese hamster lung (V79) cells in vitro, and the frequency of multinucleated cells (Fmu) and that of micronucleate… (More)