Differential effects of airway afferent nerve subtypes on cough and respiration in anesthetized guinea pigs.

@article{Chou2008DifferentialEO,
  title={Differential effects of airway afferent nerve subtypes on cough and respiration in anesthetized guinea pigs.},
  author={Yang-Ling Chou and Mark D Scarupa and Nanako Mori and Brendan J. Canning},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2008},
  volume={295 5},
  pages={R1572-84}
}
The hypothesis that respiratory reflexes, such as cough, reflect the net and often opposing effects of activation of multiple afferent nerve subpopulations throughout the airways was evaluated. Laryngeal and tracheal mucosal challenge with either citric acid or mechanical probing reliably evoked coughing in anesthetized guinea pigs. No other stimulus reliably evoked coughing in these animals, regardless of route of administration and despite some profound effects on respiration. Selectively… CONTINUE READING
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