Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice.

@article{Guo2009DifferentialEO,
  title={Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice.},
  author={Ren Xuan Guo and Christelle Anaclet and Jennifer C. Roberts and R{\'e}gis Parmentier and Meiqian Zhang and G{\'e}rard Guidon and Colette Buda and J. P. Sastre and Jinqiu Feng and Patricia Franco and Susan H. Brown and Neil Upton and Andrew D. Medhurst and Jian Sheng Lin},
  journal={British journal of pharmacology},
  year={2009},
  volume={157 1},
  pages={104-17}
}
BACKGROUND AND PURPOSE Histamine H3 receptor antagonists are currently being evaluated in clinical trials for a number of central nervous system disorders including narcolepsy. These agents can increase wakefulness (W) in cats and rodents following acute administration, but their effects after repeat dosing have not been reported previously. EXPERIMENTAL APPROACH EEG and EMG recordings were used to investigate the effects of acute and repeat administration of the novel H3 antagonist GSK189254… CONTINUE READING
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