Differential effects of acute and chronic treatment with the α2-adrenergic agonist, lofexidine, on cocaine self-administration in rhesus monkeys.

@article{Kohut2013DifferentialEO,
  title={Differential effects of acute and chronic treatment with the $\alpha$2-adrenergic agonist, lofexidine, on cocaine self-administration in rhesus monkeys.},
  author={Stephen J. Kohut and Peter A. Fivel and Nancy K. Mello},
  journal={Drug and alcohol dependence},
  year={2013},
  volume={133 2},
  pages={
          593-9
        }
}
BACKGROUND Lofexidine, an α2-adrenergic agonist, is being investigated as a treatment for reducing opioid withdrawal symptoms and blocking stress-induced relapse to cocaine taking. Opioid abusers are often polydrug abusers and cocaine is one frequent drug of choice. However, relatively little is known about lofexidine interactions with cocaine. The present study investigated the effects of acute and chronic treatment with lofexidine in a pre-clinical model of cocaine self-administration… Expand
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