Differential effects of acute and chronic ethanol treatment on particular opioid peptide systems in discrete regions of rat brain and pituitary.

@article{Seizinger1983DifferentialEO,
  title={Differential effects of acute and chronic ethanol treatment on particular opioid peptide systems in discrete regions of rat brain and pituitary.},
  author={Bernd R. Seizinger and K Bovermann and Dusica Maysinger and Volker Hoellt and A. Herz},
  journal={Pharmacology, biochemistry, and behavior},
  year={1983},
  volume={18 Suppl 1},
  pages={361-9}
}
Acute ethanol treatment induced a significant increase in the tissue levels of immunoreactive (ir-) Met-enkephalin in hypothalamus, striatum and midbrain, but not in hippocampus. Levels of ir-dynorphin, ir-alpha-neo-endorphin and ir-beta-endorphin were not found to be significantly altered in brain and pituitary. Chronic ethanol treatment (by the use of ethanol liquid diet) resulted in a more than 50% decrease of the tissue levels of ir-dynorphin and ir-alpha-neo-endorphin in hypothalamus and… CONTINUE READING