Differential effects of Wilms tumor WT1 splice variants on the insulin receptor promoter.

@article{Webster1997DifferentialEO,
  title={Differential effects of Wilms tumor WT1 splice variants on the insulin receptor promoter.},
  author={Nicholas J. G. Webster and Yu-ying Kong and Prashant Sharma and Martin Haas and Saraswati V. Sukumar and B Lynn Seely},
  journal={Biochemical and molecular medicine},
  year={1997},
  volume={62 2},
  pages={139-50}
}
The Wilms tumor gene WT1 has been implicated in the early development of the kidney. Mutations in WT1 are found in a small fraction of Wilms tumor, a pediatric nephroblastoma, and Denys-Drash syndrome, characterized by genitourinary abnormalities. The WT1 gene product functions as a transcriptional repressor of growth factor-related genes. The kidney is one of the major sites of insulin action in vivo and expresses high levels of insulin receptors (IR). IR expression has been detected during… CONTINUE READING