Differential effects of U46619 on renal regional hemodynamics in the rat: involvement of endothelin.

@article{Hantz2001DifferentialEO,
  title={Differential effects of U46619 on renal regional hemodynamics in the rat: involvement of endothelin.},
  author={H Hantz and A Adesuyi and Olorunfemi Adebayo},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={299 1},
  pages={372-6}
}
Many vasoactive agents produce qualitatively similar effects on blood flow in the renal cortex and medulla, evoking reductions or increases in blood flow in both regions. We demonstrated previously that endothelin-1 (ET-1) is an exception because it evoked an increase in medullary perfusion despite a potent cortical vasoconstriction ( Hercule and Oyekan 2000). We report here that U46619 (11,9 epoxymethano-prostaglandin H2), a selective agonist of prostaglandin H2 (PGH2)/thromboxane A2 (TxA2… CONTINUE READING