Differential effects of TRPV channel block on polymodal activation of rat cutaneous nociceptors in vitro

@article{Pierre2009DifferentialEO,
  title={Differential effects of TRPV channel block on polymodal activation of rat cutaneous nociceptors in vitro},
  author={Michael Pierre and Peter W Reeh and Katharina Zimmermann},
  journal={Experimental Brain Research},
  year={2009},
  volume={196},
  pages={31-44}
}
The capsaicin receptor TRPV1 is a polymodal sensory transducer molecule in the pain pathway. TRPV1 integrates noxious heat, tissue acidosis and chemical stimuli which are all known to cause pain. Studies on TRPV1-deficient mice suggest that TRPV1 is essential for acid sensing by nociceptors and for thermal hyperalgesia in inflammation of the skin, but not for transducing noxious heat. After TRPV1, other TRPV channels were cloned with polymodal properties and sensitivity to noxious heat, named… CONTINUE READING