# Differential effects of TNF and LTα in the host defense against M. bovis BCG

@article{Bopst2001DifferentialEO,
title={Differential effects of TNF and LT$\alpha$ in the host defense against M. bovis BCG},
author={M. Bopst and I. Garcia and R. Guler and M. Olleros and T. R{\"u}licke and Matthias M{\"u}ller and Stefanie Wyss and K. Frei and M. Le Hir and H. Eugster},
journal={European Journal of Immunology},
year={2001},
volume={31}
}
• M. Bopst, +7 authors H. Eugster
• Published 2001
• Biology, Medicine
• European Journal of Immunology
Signaling via TNF receptor type 1 (TNFR1) was shown to be crucial in host defense against the intracellular pathogens L. monocytogenes, M. tuberculosis and M. bovis. Toinvestigate the function of TNF and LTα  in host defense against M. bovis, mice double deficient for TNF and LTα  (TNF / LTα – / –), TNF / LTα – / – mice complemented with a murine LTα  transgene (TNF– / –) and LTα – / – mice were infected with BCG and the ensuing pathology was investigated. Control mice showed a normal host… Expand