Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E release.

Abstract

In A549 pulmonary cells, the dexamethasone- and budesonide-dependent repression of interleukin-1beta-induced prostaglandin E2 release was mimicked by the steroid antagonist, RU486. Conversely, whereas dexamethasone and budesonide were highly effective inhibitors of interleukin-1beta-induced cyclooxygenase (COX)/prostaglandin E synthase (PGES) activity and… (More)

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Cite this paper

@article{Chivers2004DifferentialEO, title={Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E release.}, author={Joanna E. Chivers and Lisa M. Cambridge and Matthew C. Catley and Judith Choi-wo Mak and Louise E Donnelly and Peter J Barnes and Robert Newton}, journal={European journal of biochemistry}, year={2004}, volume={271 20}, pages={4042-52} }