Differential effects of PPARγ activation by the oral antidiabetic agent pioglitazone in Barrett’s carcinoma in vitro and in vivo

Abstract

The nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARγ) is a key transcription factor regulating genes involved in adipogenesis, glucose homeostasis and cell differentiation. Moreover, PPARγ has been demonstrated to control proliferation and apoptosis in various cancer cells. We investigated the biological effects of PPAR… (More)
DOI: 10.1007/s00535-009-0086-y

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