Differential effects of PCSK9 variants on risk of coronary disease and ischaemic stroke

@inproceedings{Hopewell2018DifferentialEO,
  title={Differential effects of PCSK9 variants on risk of coronary disease and ischaemic stroke},
  author={Jemma C. Hopewell and Rainer Malik and Elsa Vald{\'e}s-M{\'a}rquez and Bradford Worrall and Rory Collins},
  booktitle={European heart journal},
  year={2018}
}
Aims PCSK9 genetic variants that have large effects on low-density lipoprotein cholesterol (LDL-C) and coronary heart disease (CHD) have prompted the development of therapeutic PCSK9-inhibition. However, there is limited evidence that PCSK9 variants are associated with ischaemic stroke (IS). Methods and results Associations of the loss-of-function PCSK9… CONTINUE READING