Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.

@article{Hans2008DifferentialEO,
  title={Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.},
  author={Chetan P Hans and Mourad Zerfaoui and Amarjit S Naura and Andrew D. Catling and A Hamid Boulares},
  journal={Cardiovascular research},
  year={2008},
  volume={78 3},
  pages={
          429-39
        }
}
AIMS The aim of this study was to take a combination of animal and cell culture approaches to examine the individual responses of vascular cells to varying inflammatory factors in order to gain insights on the mechanism(s) by which poly(ADP-ribose) polymerase (PARP) inhibition promotes factors of plaque stability. METHODS AND RESULTS Apolipoprotein (ApoE(-/-)) mice fed a high-fat diet were used as a model of atherosclerosis. Primary endothelial cells, smooth muscle cells (SMCs), and ex-vivo… CONTINUE READING

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