Differential effects of N-cadherin-mediated adhesion on the development of myotomal waves.

@article{Cinnamon2006DifferentialEO,
  title={Differential effects of N-cadherin-mediated adhesion on the development of myotomal waves.},
  author={Yuval Cinnamon and Raz Ben-Yair and Chaya Kalcheim},
  journal={Development},
  year={2006},
  volume={133 6},
  pages={1101-12}
}
Myotomal fibers form by a first wave of pioneer myoblasts from the medial epithelial somite, and by a second wave from all four lips of the dermomyotome. Then, a third wave of mitotic progenitors colonizes the myotome, initially stemming from the extreme lips and, later, from the central dermomyotome sheet. In vitro studies have suggested that N-cadherin plays a role in myogenesis, but its role in vivo remains poorly understood. We find that during the growth phase of the dermomyotome sheet… CONTINUE READING

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