Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance.

@article{Singh2009DifferentialEO,
  title={Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance.},
  author={Rajat Singh and Yongjun Wang and Youqing Xiang and K. O. Tanaka and William A. Gaarde and Mark J. Czaja},
  journal={Hepatology},
  year={2009},
  volume={49 1},
  pages={87-96}
}
UNLABELLED Activation of c-Jun N-terminal kinase (JNK) has been implicated as a mechanism in the development of steatohepatitis. This finding, together with the reported role of JNK signaling in the development of obesity and insulin resistance, two components of the metabolic syndrome and predisposing factors for fatty liver disease, suggests that JNK may be a central mediator of the metabolic syndrome and an important therapeutic target in steatohepatitis. To define the isoform-specific… CONTINUE READING