Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls

@article{Durston2005DifferentialEO,
  title={Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls},
  author={Sarah Durston and John A. Fossella and B. J. Casey and Hilleke E. Hulshoff Pol and Adriana Galvan and Hugo G. Schnack and Mark Peter Steenhuis and Ruud B. Minderaa and Jan K. Buitelaar and Ren{\'e} S. Kahn and Herman van Engeland},
  journal={Molecular Psychiatry},
  year={2005},
  volume={10},
  pages={678-685}
}
Genetic influences on behavior are complex and, as such, the effect of any single gene is likely to be modest. Neuroimaging measures may serve as a biological intermediate phenotype to investigate the effect of genes on human behavior. In particular, it is possible to constrain investigations by prior knowledge of gene characteristics and by including samples of subjects where the distribution of phenotypic variance is both wide and under heritable influences. Here, we use this approach to show… CONTINUE READING
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