Differential effects of DNA double-strand break repair pathways on single-strand and self-complementary adeno-associated virus vector genomes.


The linear DNA genomes of recombinant adeno-associated virus (rAAV) gene delivery vectors are acted upon by multiple DNA repair and recombination pathways upon release into the host nucleus, resulting in circularization, concatemer formation, or chromosomal integration. We have compared the fates of single-strand rAAV (ssAAV) and self-complementary AAV… (More)
DOI: 10.1128/JVI.00641-10


8 Figures and Tables