Differential effects of Cbl isoforms on Egfr signaling in Drosophila

  title={Differential effects of Cbl isoforms on Egfr signaling in Drosophila},
  author={Li-Mei Pai and Pei-Yu Wang and Shu-Ru Chen and Gail Barcelo and Wei-Ling Chang and Laura A. Nilson and Trudi Sch{\"u}pbach},
  journal={Mechanisms of Development},
The Cbl family of proteins downregulate epidermal growth factor receptor (Egfr) signaling via receptor internalization and destruction. These proteins contain two functional domains, a RING finger domain with E3 ligase activity, and a proline rich domain mediating the formation of protein complexes. The Drosophila cbl gene encodes two isoforms, D-CblS and D-CblL. While both contain a RING finger domain, the proline rich domain is absent from D-CblS. We demonstrate that expression of either… CONTINUE READING


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