Differential effects of Ca2+ and cAMP on transcription mediated by MEF2D and cAMP-response element-binding protein in hippocampal neurons.

@article{Belfield2006DifferentialEO,
  title={Differential effects of Ca2+ and cAMP on transcription mediated by MEF2D and cAMP-response element-binding protein in hippocampal neurons.},
  author={Johanna L Belfield and Chris Whittaker and Muhammed Z Cader and Sangeeta Chawla},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 38},
  pages={27724-32}
}
In neurons, the second messengers Ca(2+) and cAMP are mediators of transcriptional responses that are important for the development and function of the nervous system. The pro-survival neuronal transcription factors cAMP-response elementbinding protein (CREB) and myocyte enhancer factor-2 (MEF2) both stimulate gene expression in response to activity-dependent increases in the concentration of intracellular Ca(2+) ions. CREB is also activated by increases in intracellular cAMP. Here we have… CONTINUE READING

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We have also shown that cAMP inhibits Ca(2+)-induced nuclear export of the MEF2 co - repressor HDAC5 and prevents Ca(2+)-stimulated nuclear import of the MEF2 co - activator NFAT3/c4 .
We have also shown that cAMP inhibits Ca(2+)-induced nuclear export of the MEF2 co - repressor HDAC5 and prevents Ca(2+)-stimulated nuclear import of the MEF2 co - activator NFAT3/c4 .
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