Differential effects of CD40 stimulation on normal and neoplastic cell growth.


CD40 is a molecule in the tumor necrosis factor receptor/nerve growth factor receptor (TNFR/NGFR) family that is present on both normal and neoplastic B lineage cells. It is also expressed on carcinoma and melanoma cells and can be augmented with interferon gamma. CD40 stimulation in normal B cells has been demonstrated to promote normal B cell differentiation and growth in vitro. In contrast to these effects, CD40 stimulation by either anti-CD40 antibodies or a recombinant soluble CD40 ligand can inhibit the growth of human breast carcinomas and aggressive histology B lymphomas in vitro and in vivo. This is believed to occur by activation-induced cell death (AICD) in which stimuli that promote the growth of normal cell types inhibit the growth of neoplastic counterparts. This occurs through the induction of apoptosis, necrosis and/or cell cycle arrest. Thus, CD40 stimulation may be of potential clinical use in the treatment of carcinomas and B cell lymphomas. This review shall provide an overview of the various effects of CD40 stimulation on both normal and neoplastic cell types.

3 Figures and Tables


Citations per Year

88 Citations

Semantic Scholar estimates that this publication has 88 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Ziebold2000DifferentialEO, title={Differential effects of CD40 stimulation on normal and neoplastic cell growth.}, author={J L Ziebold and Julie A. Hixon and Ashleigh Susan Boyd and William Joseph Murphy}, journal={Archivum immunologiae et therapiae experimentalis}, year={2000}, volume={48 4}, pages={225-33} }