Differential effects of CCK-JMV-180 on food intake in rats and mice

  title={Differential effects of CCK-JMV-180 on food intake in rats and mice},
  author={K. Asin and L. Bednarz},
  journal={Pharmacology Biochemistry and Behavior},
  • K. Asin, L. Bednarz
  • Published 1992
  • Biology, Medicine
  • Pharmacology Biochemistry and Behavior
  • Boc-Tyr(SO3)-Nle-Gly-Trp-Nle-Asp-2-phenylether ester (CCK-JMV-180) has been reported to be a CCK-based heptipeptide with novel in vitro properties. Based on studies conducted in rat and mouse pancreatic acini, it has been proposed that the compound acts as an agonist at the high-affinity site and an antagonist at the low-affinity site in the rat, but as an agonist at both sites in the mouse. In the present study, we examined the effects of CCK-JMV-180 on locomotor activity in the rat and on… CONTINUE READING
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