Differential effects of BMP-2 and TGF-beta1 on chondrogenic differentiation of adipose derived stem cells.

@article{Mehlhorn2007DifferentialEO,
  title={Differential effects of BMP-2 and TGF-beta1 on chondrogenic differentiation of adipose derived stem cells.},
  author={Alexander T. Mehlhorn and Philipp Niemeyer and K Kaschte and Laurent Muller and Guenter Finkenzeller and Dominik Hartl and Norbert P. Sudkamp and Hagen Schmal},
  journal={Cell proliferation},
  year={2007},
  volume={40 6},
  pages={809-23}
}
OBJECTIVES This article addresses the interaction of transforming growth factor beta1 (TGF-beta1) and bone morphogenic protein 2 (BMP-2) during osteo-chondrogenic differentiation of adipose-derived adult stem cells (ASC). TGF-beta1 was expected to modulate the BMP-2-induced effects through transcriptional regulation of Dlx-5, Msx-2 and Runx-2. MATERIALS AND METHODS Encapsulated ASC were cultured for 14 days in medium containing TGF-beta1 and/or BMP-2. mRNA expression of the extracellular… CONTINUE READING

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