Differential effects of BCL-2 on survival and proliferation of human B-lymphoma cells following γ-irradiation

  title={Differential effects of BCL-2 on survival and proliferation of human B-lymphoma cells following γ-irradiation},
  author={Anne E. Milner and Roger J. A. Grand and Andrew T. Vaughan and Richard Armitage and Christopher D Gregory},
Bcl-2 can inhibit apoptosis induced by a variety of stimuli, including radiation and its presence in tumour cells would be expected to indicate poor prognosis. Bcl-2-expressing tumours, however, are often low-grade and highly responsive to therapy. To investigate this apparent paradox, we analysed in vitro the responses of Burkitt lymphoma (BL) cells to γ-irradiation in the presence and absence of Bcl-2. High-level expression of Bcl-2 was shown to promote BL cell survival following irradiation… CONTINUE READING


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