Differential effects of Alzheimer's disease and Huntington's disease on the performance of mental rotation

@article{Lineweaver2005DifferentialEO,
  title={Differential effects of Alzheimer's disease and Huntington's disease on the performance of mental rotation},
  author={Tara T Lineweaver and David P. Salmon and Mark W. Bondi and Jody Corey-Bloom},
  journal={Journal of the International Neuropsychological Society},
  year={2005},
  volume={11},
  pages={30 - 39}
}
The ability to spatially rotate a mental image was compared in patients with Alzheimer's disease (AD; n = 18) and patients with Huntington's disease (HD; n = 18). Compared to their respective age-matched normal control (NC) group, the speed, but not the accuracy, of mental rotation abnormally decreased with increasing angle of orientation for patients with HD. In contrast, the accuracy, but not the speed, of rotation abnormally decreased with increasing angle of orientation for patients with AD… Expand
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2
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References

SHOWING 1-10 OF 95 REFERENCES
Differential perceptual-spatial impairment in Huntington's and Alzheimer's dementias.
TLDR
A double dissociation was found: the performance of patients with AD was found to be significantly impaired on tasks involving extrapersonal perception and construction but not on the test of egocentric space, while salient deficits were apparent when manipulation of personal space was required. Expand
Spatial disorientation in Alzheimer's disease.
TLDR
Investigation of spatial disorientation in ambulatory patients meeting "probable" Alzheimer's disease criteria found that neuropsychologic measures of memory and visuoconstructive functions, but not disease severity, attention, or language impairment, emerged as significant predictors of spatialdisorientation. Expand
Quantitative and qualitative analyses of clock drawings in Alzheimer's and Huntington's disease
TLDR
While both DAT and HD patients have significant visuoconstructive difficulties even in the early stages of their disorders, the specific cognitive processes underlying their quantitative impairments are quite different. Expand
Greater Relative Impairment of Object Recognition Than of Visuospatial Abilities in Alzheimer's Disease
Histological investigation in Alzheimer's disease (AD) has indicated that the concentration of neurofibrillary tangles in inferotemporal cortex (IT) is greater than that found in posterior parietalExpand
Prevalence of visual deficits in Alzheimer's disease.
TLDR
The results indicate that visual dysfunction, especially on Backward Masking, is a common sign of AD and indicates a high vulnerability in AD of pattern vision, moderate vulnerability of spatial vision, and low vulnerability of motion and flicker perception. Expand
Comparison of the neuropsychological deficits associated with early and advanced Huntington's disease.
TLDR
The results suggest that the cognitive deficits of patients with HD do not develop uniformally; memory disorders are early focal signs that precede the patients' more widespread intellectual deterioration. Expand
The Neuropsychology of Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive degenerative brain disorder that results in a profound global dementia characterized by severe amnesia with additional deficits in language, “executive”Expand
Development of neuropsychological deficits in Huntington's disease.
TLDR
The findings suggest that deficits in HD do not develop at a uniform rate; deficits in cognitive flexibility occur in later stages of the disease; and visuospatial and auditory memory deficits are very early signs and are present in some asymptomatic offspring. Expand
Visual cortical dysfunction in Alzheimer's disease evaluated with a temporally graded "stress test" during PET.
TLDR
The finding that the Alzheimer's disease group had abnormal visual cortical function emphasizes the importance of clinical visuospatial evaluation of patients with Alzheimer's Disease to fully understand symptom production and to plan interventions. Expand
A comparative study of simple and choice reaction time in Parkinson's, Huntington's and cerebellar disease.
TLDR
It is concluded that similar reaction time deficits are found in Parkinson's disease, in patients with other disorders of the basal ganglia (Huntington's disease), as well as those with a disease sparing the basal Ganglia (cerebellar disease). Expand
...
1
2
3
4
5
...