Differential effects of Akt1 signaling on short- versus long-term consequences of myocardial infarction and reperfusion injury

@article{Ma2014DifferentialEO,
  title={Differential effects of Akt1 signaling on short- versus long-term consequences of myocardial infarction and reperfusion injury},
  author={Lining Ma and Bethany A Kerr and Sathyamangla V. Naga Prasad and Tatiana V. Byzova and Payaningal R Somanath},
  journal={Laboratory Investigation},
  year={2014},
  volume={94},
  pages={1083-1091}
}
A specific role for Akt1 in events following myocardial infarction (MI) and ischemia/reperfusion (I/R) injury is not known. We aimed to determine whether Akt1 deletion in in vivo mouse models of MI and after ischemia I/R injury would alter myocyte survival, cardiac function, and fibrosis. Akt1+/+ and Akt1−/− mice were subjected to MI and I/R, followed by assessment of downstream signaling events and functional consequences. Although no difference in infarct size following short-term MI was… CONTINUE READING
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