Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats.

@article{Hayes2009DifferentialEO,
  title={Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats.},
  author={Dave J. Hayes and Tera M Mosher and Andrew J. Greenshaw},
  journal={Behavioural brain research},
  year={2009},
  volume={197 2},
  pages={323-30}
}
RATIONALE Numerous studies indicate a role for both the serotonin 2C receptor (5-HT(2C)) and the nicotinic acetylcholine receptor in locomotion, reinforcement and motivated behaviours. Nicotine, a potent nicotinic acetylcholine receptor agonist, interacts with the dopaminergic and serotonergic systems and is known to positively affect reward-related behaviours. OBJECTIVES The current study examined the effects of 5-HT(2C) receptor activation on nicotine-induced (0.6 mg/kg) place conditioning… CONTINUE READING
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Increased expressionof 5 - HT 6 receptors in the nucleus accumbens blocks the rewarding but not psychomotor activating properties of cocaine

  • FergusonSM, ES Mitchell, JF Neumaier
  • Biological Psychiatry
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