Differential effects of 5‐aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo

@article{Finlan2005DifferentialEO,
  title={Differential effects of 5‐aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo},
  author={Lee E. Finlan and N M Kernohan and G Thomson and Paula E. Beattie and Ted R. Hupp and Sally Helen Ibbotson},
  journal={British Journal of Dermatology},
  year={2005},
  volume={153}
}
Background  Phosphorylation of the tumour suppressor p53 by the CK2/FACT pathway plays a central role in suppressing ultraviolet (UV)‐induced skin cancer in animal models. Although p53 protein stabilization is induced after solar‐simulated irradiation of human skin in vivo, p53 phosphorylation has not been defined. 

Adverse effects of topical photodynamic therapy

  • S. Ibbotson
  • Medicine
    Photodermatology, photoimmunology & photomedicine
  • 2011
TLDR
A review explores the adverse effects of topical PDT, particularly for the treatment of superficial non‐melanoma skin cancer and dysplasia.

Adverse effects of topical photodynamic therapy: a consensus review and approach to management

Topical photodynamic therapy (PDT) is widely used to treat superficial nonmelanoma skin cancer and dysplasia, and is generally well tolerated. However, as with all treatments, adverse effects may

Photodynamic therapy.

Enoxacin with UVA Irradiation Induces Apoptosis in the AsPC1 Human Pancreatic Cancer Cell Line Through ROS Generation.

TLDR
It is suggested that UVA irradiation activates enoxacin, after which activated en oxacin induces apoptosis of AsPC1 cells through generation of reactive oxygen species, which may be a useful method for treating pancreatic cancer.

CK2-site Phosphorylation of p53 is Induced in ΔNp63 Expressing Basal Stem Cells in UVB Irradiated Human Skin

TLDR
A selective induction of p53 phosphorylation at the CK2-site in the basal cells of UV irradiated human skin is found and this data identify a physiological model with which to identify signalling pathways that mediate cross-talk between p63αΔΝ and activating p53 kinase pathways after DNA damage in basal cell populations.

Down-regulation of heat-shock protein 27-induced resistance to photodynamic therapy in oral cancer cells.

  • Jisun KimHyun-Chul Jung Okjoon Kim
  • Biology
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • 2013
TLDR
Down-regulation of HSP27 restored cell survival in HP-PDT-induced apoptotic KB cells and confers resistance to PDT through interruption of apoptotic protein activity in PDT-induced cell death.

Psoralen reverses docetaxel-induced multidrug resistance in A549/D16 human lung cancer cells lines.

Guidelines for topical photodynamic therapy: update

Multicentre randomized controlled studies now demonstrate high efficacy of topical photodynamic therapy (PDT) for actinic keratoses, Bowen’s disease (BD) and superficial basal cell carcinoma (BCC),

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TLDR
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TLDR
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