Differential effects of 192IgG-saporin and NMDA-induced lesions into the basal forebrain on cholinergic activity and taste aversion memory formation.

@article{Gutierrez1999DifferentialEO,
  title={Differential effects of 192IgG-saporin and NMDA-induced lesions into the basal forebrain on cholinergic activity and taste aversion memory formation.},
  author={Hector Gutierrez and Rafael Gutierrez and R Silva-Gandarias and Jimena Estrada and Mar{\'i}a Isabel Miranda and Federico Berm{\'u}dez-Rattoni},
  journal={Brain research},
  year={1999},
  volume={834 1-2},
  pages={136-41}
}
Mnemonic deficits resulting from excitotoxic lesion of the basal forebrain have been classically attributed to the resulting depletion of cortical acetylcholine activity. In this study, we have performed a detailed analysis of the cholinergic status of the insular cortex (IC) following local injections of either 192IgG-saporin (192IgG-sap) or N-methyl-D-aspartate (NMDA) directly into the nucleus basalis magnocellularis (NBM). By means of in vivo microdialysis, we show that the immunotoxin… CONTINUE READING
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