Differential effects of 17beta-estradiol, conjugated equine estrogen, and raloxifene on mRNA expression, aggregation, and secretion in platelets.

Abstract

Changes in platelet functions could contribute to thrombotic risk associated with estrogen treatments. This study was designed to test the hypothesis that three clinically relevant estrogenic treatments affect platelet function comparably. Adult female pigs were ovariectomized and randomized to either no treatment or treatment with oral 17 beta-estradiol (2… (More)

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@article{Jayachandran2005DifferentialEO, title={Differential effects of 17beta-estradiol, conjugated equine estrogen, and raloxifene on mRNA expression, aggregation, and secretion in platelets.}, author={Muthuvel Jayachandran and Rajarshi Mukherjee and Thomas Steinkamp and Peter Labreche and Margarita P Bracamonte and Hiroya Okano and Whyte G. Owen and Virginia M Miller}, journal={American journal of physiology. Heart and circulatory physiology}, year={2005}, volume={288 5}, pages={H2355-62} }