Differential effectiveness of selected non‐psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment

  title={Differential effectiveness of selected non‐psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment},
  author={Attila Ol{\'a}h and Arnold Markovics and Judit Szab{\'o}-Papp and P{\'a}lma T{\'i}mea Szab{\'o} and Colin G. Stott and Christos C. Zouboulis and Tam{\'a}s B{\'i}r{\'o}},
  journal={Experimental Dermatology},
Acne is a common skin disease characterized by elevated sebum production and inflammation of the sebaceous glands. [] Key Method Viability and proliferation of human SZ95 sebocytes were investigated by MTT and CyQUANT assays; cell death and lipid synthesis were monitored by DilC1 (5)-SYTOX Green labelling and Nile Red staining, respectively. Inflammatory responses were investigated by monitoring expressions of selected cytokines upon lipopolysaccharide treatment (RT-qPCR, ELISA). Up to 10 μm, the…

Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA2)

The concept that NA may be effective in suppressing sebum production in vivo is supported, and NA, and HCA2 activators in general, are introduced as novel, potent and most likely safe sebostatic agents, with possible anti‐acne potential.

Effects of Rare Phytocannabinoids on the Endocannabinoid System of Human Keratinocytes

It is demonstrated that rare pCBs modulate the gene and protein expression of distinct ECS elements differently, as well as the content of endocannabinoid(-like) compounds.

The Anti-Inflammatory Effects of Cannabidiol (CBD) on Acne

CBD and other cannabis constituents such as cannabis seeds were found to reduce inflammation and expression of inflammatory cytokines including TNF-α and IL-1β when evaluated in acne-like conditions and treatment with these cannabis extracts was found to be safe and well tolerated, strengthening the prospect of CBD as an anti-inflammatory therapeutic for acne.

Cannabis sativa and Skin Health: Dissecting the Role of Phytocannabinoids.

The incomplete knowledge of the role of the endocannabinoid system in skin disorders emerged as an important limit for pharmacological investigations, and the limited studies conducted on C. sativa extracts suggested a higher potency than single phytocannabinoids, thus stimulating new research on phytOCannabinoid interaction.

Salicylic acid treats acne vulgaris by suppressing AMPK/SREBP1 pathway in sebocytes

Investigation of the anti‐acne properties of SA in human SEB‐1 sebocytes confirmed that SA suppressed the levels of cytokines and major pathogenic proteins around acne lesions, which supports the mechanisms suggested by the in vitro experiments.

In Vitro and Clinical Evaluation of Cannabigerol (CBG) Produced via Yeast Biosynthesis: A Cannabinoid with a Broad Range of Anti-Inflammatory and Skin Health-Boosting Properties

Cannabigerol’s broad range of in vitro and clinical skin health-promoting activities demonstrates its strong potential as a safe, effective ingredient for topical use and suggests there are areas where it may be more effective than CBD.

Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System

An overview of the available skin-relevant endo- and phytocannabinoid literature is given with a special emphasis on the putative translational potential, and to highlight promising future research directions as well as existing challenges.



Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes.

It is suggested that, due to the combined lipostatic, antiproliferative, and antiinflammatory effects, CBD has potential as a promising therapeutic agent for the treatment of acne vulgaris.

Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor‐2‐mediated signaling

  • Nóra DobrosiB. Tóth T. Bíró
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2008
It is suggested that human sebocytes utilize a paracrine‐autocrine, endogenously active, CB2‐mediated endocannabinoid signaling system for positively regulating lipid production and cell death, and deserve to be explored in the management of skin disorders characterized by sebaceous gland dysfunctions.

Are cannabidiol and Δ9‐tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

The evidence indicates that CBD and THCV are not rimonabant‐like in their action and thus appear very unlikely to produce unwanted CNS effects, illustrating how in vitro mechanistic studies do not always predict in vivo pharmacology and underlie the necessity of testing compounds in vivo before drawing any conclusion on their functional activity at a given target.

New developments in our understanding of acne pathogenesis and treatment

A summarized update of the current knowledge of the pathobiology of acne vulgaris and new treatment concepts that have emerged in the last 3 years is provided.

Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid.

In vivo, CBG hampers colon cancer progression in vivo and selectively inhibits the growth of CRC cells, an effect shared by other TRPM8 antagonists, and should be considered translationally in CRC prevention and cure.

Isotretinoin: state of the art treatment for acne vulgaris

  • R. GancevicieneC. Zouboulis
  • Medicine
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • 2010
Physician's experience, coupled with proper patient selection, dose adjustment or discontinuation of treatment, and routine monitoring for potential toxicity, has allowed the successful prevention and management of most adverse effects associated with isotretinoin.

Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model.

Frontiers in sebaceous gland biology and pathology

Abstract:  The development of experimental models for the in vitro study of human sebaceous gland turned down the theory of a phylogenetic relict and led to the identification of several, unknown or

Endocannabinoid signaling at the periphery: 50 years after THC.