Differential effect of urotensin II on vascular tone in normal subjects and patients with chronic heart failure.

@article{Lim2004DifferentialEO,
  title={Differential effect of urotensin II on vascular tone in normal subjects and patients with chronic heart failure.},
  author={Melissa Chen Yi Lim and Suzy Y Honisett and Christopher D Sparkes and Paul A Komesaroff and Andrew R. Kompa and Henry Krum},
  journal={Circulation},
  year={2004},
  volume={109 10},
  pages={1212-4}
}
BACKGROUND Urotensin II (U-II) is a novel vasoactive peptide that also has direct hypertrophic and profibrotic effects on the myocardium. Upregulation of U-II and its receptor has been observed within the heart of patients with chronic heart failure (CHF). Furthermore, plasma levels of U-II have been found to be elevated in some but not all studies in such patients. However, the functional consequences of activation of the U-II system in patients with CHF, assessed by direct administration of… CONTINUE READING

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