Differential effect of trilostane on the progestin milieu in the pregnant mare.

  title={Differential effect of trilostane on the progestin milieu in the pregnant mare.},
  author={W. Schutzer and J. Kerby and D. Holtan},
  journal={Journal of reproduction and fertility},
  volume={107 2},
  • W. Schutzer, J. Kerby, D. Holtan
  • Published 1996
  • Biology, Medicine
  • Journal of reproduction and fertility
  • Trilostane, a competitive inhibitor of 3 beta-hydroxysteroid dehydrogenase, was administered intravenously to pregnant mares (n = 3) between day 277 and day 282 of gestation to determine its effect on the progestin milieu. In addition, placental tissue from mares at mid-gestation (150-300 days) (n = 4) were exposed to either deuterium-labelled pregnenolone alone or deuterium-labelled pregnenolone and trilostane to examine the effect of trilostane on placental metabolism of pregnenolone. Blood… CONTINUE READING
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