Differential effect of tetradecythioacetic acid on the renin-angiotensin system and blood pressure in SHR and 2-kidney, 1-clip hypertension.

@article{Bivol2007DifferentialEO,
  title={Differential effect of tetradecythioacetic acid on the renin-angiotensin system and blood pressure in SHR and 2-kidney, 1-clip hypertension.},
  author={Liliana Monica Bivol and Rolf Kristian Berge and Bjarne Magnus Iversen},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={293 3},
  pages={
          F839-45
        }
}
The tetradecythioacetic acid (TTA) is a modified fatty acid known to exhibit pleiotropic effects. First, we compared the effect of TTA on the blood pressure in spontaneously hypertensive rats (SHR) with two-kidney, one-clip (2K1C)-hypertensive rats. Second, we examined mechanisms involved in the blood pressure reduction. TTA had minor effect on systolic blood pressure (SBP) in young SHR up to 8 wk of age. In 2K1C we confirmed the blood pressure-lowering effect of TTA (SBP: 173 +/- 4 before vs… 
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Tetradecylthioacetic acid downregulates cyclooxygenase 2 in the renal cortex of two-kidney, one-clip hypertensive rats.
TLDR
Results indicate that, after 6 wk of treatment, TTA downregulated the COX2 activity, which have potentially important effects on the regulation of renal hemodynamics but does not explain TTAs ability to lower BP.
The tetradecylthioacetic acid ( TTA ) prevents the inflammatory response in 2-kidney , 1-clip hypertension
TLDR
The results indicate that TTA has potent anti-inflammatory effect in 2K1C by inhibition of p50/p65 NF-kB subunits activation, by reduction of cytokines production and ROS, and enhanced NO production.
Tetradecylthioacetic acid prevents the inflammatory response in two-kidney, one-clip hypertension.
TLDR
The results indicate that TTA has a potent anti-inflammatory effect in 2K1C by inhibition of p50/p65 NF-kappaB subunit activation, reduction of cytokines production and ROS, and enhanced NO production.
Antihypertensive effect of passion fruit peel extract and its major bioactive components following acute supplementation in spontaneously hypertensive rats.

References

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TLDR
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TLDR
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TLDR
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