Differential effect of steady versus oscillating flow on bone cells.

  title={Differential effect of steady versus oscillating flow on bone cells.},
  author={Christopher Rae Jacobs and Clare E. Yellowley and B. R. Davis and Zhiyi Zhou and John M. Cimbala and Henry J Donahue},
  journal={Journal of biomechanics},
  volume={31 11},
Loading induced fluid flow has recently been proposed as an important biophysical signal in bone mechanotransduction. Fluid flow resulting from activities which load the skeleton such as standing, locomotion, or postural muscle activity are predicted to be dynamic in nature and include a relatively small static component. However, in vitro fluid flow experiments with bone cells to date have been conducted using steady or pulsing flow profiles only. In this study we exposed osteoblast-like hFOB… CONTINUE READING
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