Differential effect of short-term REM sleep deprivation on NGF and BDNF protein levels in the rat brain

@article{Sei2000DifferentialEO,
  title={Differential effect of short-term REM sleep deprivation on NGF and BDNF protein levels in the rat brain},
  author={Hiroyoshi Sei and Daisuke Saitoh and Kei Yamamoto and Kyoji Morita and Yusuke Morita},
  journal={Brain Research},
  year={2000},
  volume={877},
  pages={387-390}
}
View on Elsevier
doi.org
95 Citations
Highly Influential Citations
3
Background Citations
27
Methods Citations
6
Results Citations
2

95 Citations

Citation Type

Citation Type

Sleep deprivation effects on growth factor expression in neonatal rats: a potential role for BDNF in the mediation of delta power.
TLDR
It is concluded that cortical BDNF expression reflects the onset of adult sleep-homeostatic response, whereas the profile of expression of both growth factors suggests a trophic effect of mild sleep deprivation.
Short-term sleep disturbance enhances brain-derived neurotrophic factor gene expression in rat hippocampus by acting as internal stressor
TLDR
The possibility that short-term disturbance of the sleep/wake cycle and, hence, the partial reduction of non-REM sleep duration, might exert a potential influence on neuronal and/or glial cells as an internal stressor, resulting in the elevation of BDNF gene expression in rat hippocampus is suggested.
Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB
TLDR
The results of the study suggested that sleep deprivation might act as a compensatory factor to reduce memory impairment when the animal is under severe stressful condition.
The Brain-Derived Neurotrophic Factor: Missing Link Between Sleep Deprivation, Insomnia, and Depression
TLDR
The proposed model is testable and implies that low levels and low variability in serum BDNF are associated with poor response to anti-depressive medications, electroconvulsive therapy, and REM sleep deprivation, in patients with depression.
Neurotrophic factors and sleep
Suppression of hippocampal plasticity‐related gene expression by sleep deprivation in rats
TLDR
Stepwise regression analysis suggested that loss of REM sleep underlies the effects of SD on hippocampal BDNF, Synapsin I and CREB mRNA levels, whereas loss of NREM sleep underlie the effects on CAMKII mRNA.
REM Sleep Deprivation Reverses Neurochemical and Other Depressive-Like Alterations Induced by Olfactory Bulbectomy
TLDR
It is suggested that the neurochemical complexity inflicted by the OBX model, counteracted by REMSD, is directly correlated to the nigral BDNF expression and hippocampal 5-HT levels.
Investigating the effect of crocin on memory deficits induced by total sleep deprivation (TSD) with respect to the BDNF, TrkB and ERK levels in the hippocampus of male Wistar rats
TLDR
The adverse effect of TSD on the level of proteins in the hippocampus may disrupt synaptic plasticity and transmission, which induces memory impairment and the restoration effect of crocin on the decrease in protein levels may be involved in its improvement effect on memory performance.
Influence of excessive daily sleeping and sleep quality on BDNF and NGF serum levels in adolescents.
Changes in Brain-Derived Neurotrophic Factor Expression Influence Sleep–Wake Activity and Homeostatic Regulation of Rapid Eye Movement Sleep
TLDR
Results unequivocally demonstrate that an intact BDNF system in both sexes is a critical modulator for baseline and homeostatic regulation of REM sleep and suggests that heterozygous BDNF knockdown rats are a useful animal model for the study of the cellular and molecular mechanisms of sleep regulation and cognitive functions of sleep.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 23 REFERENCES
Brain-derived neurotrophic factor enhances spontaneous sleep in rats and rabbits.
TLDR
BDNF increased time spent in non-rapid eye movement sleep (NREMS) in rats and rabbits and REMS in rabbits and current results provide further evidence that various growth factors are involved in sleep regulation.
Positive Feedback between Acetylcholine and the Neurotrophins Nerve Growth Factor and Brain‐derived Neurotrophic Factor in the Rat Hippocampus
TLDR
The reciprocal regulation of ACh, NGF and BDNF in the hippocampus suggests a novel molecular framework by which the neurotrophins might influence synaptic plasticity.
REM sleep deprivation increases the levels of tyrosine hydroxylase and norepinephrine transporter mRNA in the locus coeruleus.
Nerve growth factor enhances sleep in rabbits
Cerebellar Brain-Derived Neurotrophic Factor–TrkB Defect Associated with Impairment of Eyeblink Conditioning in StargazerMutant Mice
TLDR
The data suggest that normal BDNF expression and TrkB signal transduction in the cerebellum are necessary for learning and plasticity in the spontaneous ataxic mutant mouse stargazer.
The role of neuronal growth factors in neurodegenerative disorders of the human brain
Induction of rapid eye movement sleep by the microinjection of nerve growth factor into the pontine reticular formation of the cat
Brief Paradoxical Sleep Deprivation Impairs Reference, but Not Working, Memory in the Radial Arm Maze Task
TLDR
The results of the present experiment suggest that PSD causes deficits only in long-term forms of spatial memory.
Differential c-Fos Expression in Cholinergic, Monoaminergic, and GABAergic Cell Groups of the Pontomesencephalic Tegmentum after Paradoxical Sleep Deprivation and Recovery
TLDR
Results indicate that GABAergic neurons are active during PS and could thus be responsible for inhibiting neighboring monoaminergic neurons that may be essential in the generation of PS.
Dependence on REM sleep of overnight improvement of a perceptual skill.
TLDR
Performance of a basic visual discrimination task improved after a normal night's sleep, indicating that a process of human memory consolidation, active during sleep, is strongly dependent on REM sleep.
...
1
2
3
...