Differential effect of platelet-activating factor (PAF) receptor antagonists on peptide and PAF-stimulated prostaglandin release in unilateral ureteral obstruction.

@article{Weisman1988DifferentialEO,
  title={Differential effect of platelet-activating factor (PAF) receptor antagonists on peptide and PAF-stimulated prostaglandin release in unilateral ureteral obstruction.},
  author={Steven M. Weisman and Robert M. Freund and Diane Felsen and Edwin Darracott Vaughan},
  journal={Biochemical pharmacology},
  year={1988},
  volume={37 15},
  pages={2927-32}
}
Unilateral ureteral obstruction (UUO) results in increased renal resistance as well as in exaggerated prostaglandin (PG) release from the obstructed hydronephrotic kidney (HNK). We have reported previously that platelet-activating factor (PAF) dose-dependently stimulates the release of PGs from both the HNK and unobstructed contralateral kidney (CLK), with… CONTINUE READING