Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein.

@article{Shirasaka2011DifferentialEO,
  title={Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein.},
  author={Yoshiyuki Shirasaka and Kensuke Suzuki and Takeo Nakanishi and Ikumi Tamai},
  journal={Journal of pharmaceutical sciences},
  year={2011},
  volume={100 9},
  pages={3843-53}
}
The purpose of this study is to examine the contributions of organic anion transporting polypeptide (Oatp) and/or P-glycoprotein (P-gp) to grapefruit juice (GFJ) interaction with two statins, pravastatin and pitavastatin, which undergo negligible metabolism in rats. The two statins were found to be substrates of both Oatp1a5 and Oatp2b1, whereas pitavastatin, but not pravastatin, was a substrate of P-gp. The plasma concentration of pravastatin after oral administration was significantly… CONTINUE READING
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