Differential effect of gabapentin on neuronal and muscle calcium currents.

@article{Alden2001DifferentialEO,
  title={Differential effect of gabapentin on neuronal and muscle calcium currents.},
  author={Kris J Alden and Jes{\'u}s Manuel Mart{\'i}nez Garc{\'i}a},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={297 2},
  pages={727-35}
}
Calcium channels modulate cell function by controlling Ca(2+) influx. A main component of these proteins is the alpha 2/delta subunit. Nevertheless, how this subunit regulates channel activity in situ is unclear. Gabapentin (GBP), an analgesic and anti-epileptic agent with an unknown mechanism of action, specifically binds to the alpha 2/delta subunit. Using the patch clamp technique, we tested the effects of GBP on Ca(2+) currents from dorsal root ganglion (DRG) cells, the mediators of pain… CONTINUE READING
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