Differential effect of dehydroepiandrosterone and its steroid precursor pregnenolone against the behavioural deficits in CO-exposed mice.

@article{Maurice2000DifferentialEO,
  title={Differential effect of dehydroepiandrosterone and its steroid precursor pregnenolone against the behavioural deficits in CO-exposed mice.},
  author={Tangui Maurice and V L Phan and Françoise Sandillon and Alexandre Urani},
  journal={European journal of pharmacology},
  year={2000},
  volume={390 1-2},
  pages={
          145-55
        }
}
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28 Citations
Background Citations
8
Methods Citations
2

28 Citations

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The results showed that donepezil is a potent antiamnesic and neuroprotective compound against the neurodegeneration induced by excitotoxic insult, and its pharmacological actions as both an acetylcholinesterase inhibitor and σ1 receptor agonist contribute to its marked efficacy.

The sigma1 protein as a target for the non-genomic effects of neuro(active)steroids: molecular, physiological, and behavioral aspects.

The data demonstrating that the sigma1 receptor binds neurosteroids in physiological conditions will be reviewed and the physiological relevance of this interaction will be analyzed and the impact on physiopathological outcomes in memory and drug addiction will be illustrated.

The interaction between neuroactive steroids and the σ1 receptor function: behavioral consequences and therapeutic opportunities

Anti-amnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide (CO)

Results showed that donepezil is a potent anti-amnesic and neuroprotective compound against the neurodegeneration induced by excitotoxic insult and its pharmacological actions as both an acetylcholinesterase inhibitor and σ 1 receptor agonist contribute to its marked efficacy.

The delayed administration of dehydroepiandrosterone sulfate improves recovery of function after traumatic brain injury in rats.

Results can be interpreted to demonstrate that after a 7-day delay, the chronic administration of DHEAS to injured rats significantly improves behavioral recovery on both sensorimotor and cognitive tasks.

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Despite mixed results, the findings of various preclinical studies are generally supportive of the involvement of DHEA and DHEAS in the pathophysiology of Alzheimer's disease, showing some promise for potential benefits of these neurosteroids in the prevention and treatment.

Effects of neuroactive steroids on cochlear hair cell death induced by gentamicin

Differential involvement of the sigma1 (σ1) receptor in the anti‐amnesic effect of neuroactive steroids, as demonstrated using an in vivo antisense strategy in the mouse

The observations bring a molecular basis to the modulatory role of σ1 receptors in memory, and reveal that the anti‐amnesic action of neuroactive steroids may not similarly involve an interaction with ρ1 receptors.

References

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