Differential effect of coformycin on the cell cycle traverse of normal and simian virus 40-transformed human fibroblasts.


Normal and simian virus 40-transformed human embryonic lung fibroblasts in culture were exposed to 3.5 microM coformycin (CF). This treatment resulted in almost complete inhibition of adenosine deaminase activity in both cell lines and retarded the progress of the fibroblasts through the cell cycle, as measured by the rate of cell proliferation. There was a… (More)


3 Figures and Tables