Differential effect of caffeine intake in subjects with genetic susceptibility to Parkinson’s Disease

  title={Differential effect of caffeine intake in subjects with genetic susceptibility to Parkinson’s Disease},
  author={Prakash M. Kumar and Swe Swe Thet Paing and Hui Li and Ratnagopal Pavanni and Yih Yuen and Yun Zhao and Eng-King Tan},
  booktitle={Scientific reports},
We examined if caffeine intake has a differential effect in subjects with high and low genetic susceptibility to Parkinson's disease (PD), a common neurodegenerative disorder. A case control study involving 812 subjects consisting of PD and healthy controls were conducted. Caffeine intake assessed by a validated questionnaire and genotyping of PD gene risk variant (LRRK2 R1628P) was carried out. Compared to caffeine takers with the wild-type genotype (low genetic susceptibility), non-caffeine… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 6 times over the past 90 days. VIEW TWEETS


Publications referenced by this paper.
Showing 1-10 of 15 references

The authors declare no competing financial interests

  • C. W. Yip, Tan, +9 authors Y. Y. contributed to data collection. H.H.L. analyzed interests
  • How to cite this article: Kumar, P. M. et al…
  • 2015

is there a clinical role? Parkinsonism Relat Disord

  • D. M. Buhat, Tan, E. K. Genetic testing of LRRK2 in Parkinson’s disease
  • 20, S54–6
  • 2014


  • S. Saiki, S. Sato, Hattori, N. Molecular pathogenesis of Parkinson’s disease
  • J. Neurol Neurosurg Psychiatry. 83, 430–6
  • 2012

A Chinese Multicenter Study

  • Tan, E. K. et al. Multiple LRRK2 Variants Modulate Risk of Disease
  • Hum Mutat 31, 561–8
  • 2010

Similar Papers

Loading similar papers…