Differential effect of beta‐adrenergic receptor antagonism in basolateral amygdala on reconsolidation of aversive and appetitive memories associated with morphine in rats

  title={Differential effect of beta‐adrenergic receptor antagonism in basolateral amygdala on reconsolidation of aversive and appetitive memories associated with morphine in rats},
  author={Yan Wu and Yonghui Li and Xiaoyan Yang and Nan Sui},
  journal={Addiction Biology},
Positive and negative emotional experiences induced by addictive drugs play an important role in the development of dysfunctional drug‐related memory, which becomes resistant to extinction and contributes to high rate of relapse. Those memories may undergo a process called reconsolidation that in some cases can be disrupted by pharmacological treatment. The basolateral amygdala (BLA) has been shown to mediate the reconsolidation of drug‐related appetitive memory, but its role in withdrawal… 

Neurobiological Dissociation of Retrieval and Reconsolidation of Cocaine-Associated Memory

Targeted β-AR blockade could induce long-term deficits in drug-associated memory retrieval by reducing neuronal excitability, providing a novel method of preventing cue-elicited drug seeking and relapse.

Blockade of β-Adrenergic Receptors by Propranolol Disrupts Reconsolidation of Drug Memory and Attenuates Heroin Seeking

It is suggested that propranolol can interfere with reconsolidation of heroin memory and reduce subsequent drug seeking, making it an attractive therapeutic candidate for the treatment of opioid addiction and relapse prevention.

Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats

The data suggest that the insular cortex is involved in positive and negative affective learning related to opiate addiction, and that the GI appears to be critical for both forms of Affective learning, whereas the AI is crucial for learning associated with negative affects induced by opiate withdrawal.

Role of amygdala in drug memory

University of Birmingham Memory reconsolidation in aversive and appetitive settings

Whether principles derived from the aversive literature are applicable to appetitive settings, and also whether the expanding literature in appetitive paradigms is informative for fear memory reconsolidation are focused on.



Intra-Amygdala and Systemic Antagonism of NMDA Receptors Prevents the Reconsolidation of Drug-Associated Memory and Impairs Subsequently Both Novel and Previously Acquired Drug-Seeking Behaviors

It is demonstrated that amygdala NMDA receptors are also necessary for the reconsolidation of drug-associated memories, and drugs modulating glutamatergic transmission at the NMDA receptor may be useful in the future treatment of relapse prevention in drug addiction through memory reconsolidations blockade.

Stress Impairs Reconsolidation of Drug Memory via Glucocorticoid Receptors in the Basolateral Amygdala

It is found that rats acquired morphine CPP after conditioning, and that this CPP was inhibited by stress given immediately after re-exposure to a previously morphine-paired chamber (a reconsolidation procedure).

Disrupting Reconsolidation of Conditioned Withdrawal Memories in the Basolateral Amygdala Reduces Suppression of Heroin Seeking in Rats

It is demonstrated that drug withdrawal memories undergo protein synthesis-dependent reconsolidation in the basolateral amygdala (BLA) and a common mechanism for the reconsolidations of both appetitive and aversive drug memories is suggested.

Post-retrieval beta-adrenergic receptor blockade: effects on extinction and reconsolidation of cocaine-cue memories.

Daily post-retrieval systemic injections of propranolol decrease the conditioned preference by interfering with reconsolidation of the memory for the association between the drug-paired side and the reinforcing effects of the drug, rather than facilitating new extinction learning.

The basolateral amygdala and nucleus accumbens core mediate dissociable aspects of drug memory reconsolidation.

The results suggest that both the basolateral amygdala and nucleus accumbens core are key structures within limbic cortical-striatal circuitry where reconsolidation of a cue-drug memory occurs, however reconsolidations of memory representations formed during Pavlovian conditioning are differentially localized in each site.

Glucocorticoid enhancement of memory storage involves noradrenergic activation in the basolateral amygdala.

The results strongly suggest that beta-adrenergic activation is an essential step in mediating glucocorticoid effects on memory storage and that the BLA is a locus of interaction for these two systems.

Persistent Disruption of an Established Morphine Conditioned Place Preference

It was found that an established morphine conditioned place preference (mCPP) was persistently disrupted if protein synthesis was blocked by either anisomycin or cycloheximide after the representation of a conditioning session.