Differential effect of alkyl chain-modified ether lipids on protein kinase C autophosphorylation and histone phosphorylation.

@article{Gil1996DifferentialEO,
  title={Differential effect of alkyl chain-modified ether lipids on protein kinase C autophosphorylation and histone phosphorylation.},
  author={Carles Jovan{\'i} Gil and Eustaquio Molina and Maria Plana and Assumpta Carabaza and Francesc Cabr{\'e} and David Maule{\'o}n and Germano Carganico and Emilio Itarte},
  journal={Biochemical pharmacology},
  year={1996},
  volume={52 12},
  pages={
          1843-7
        }
}
Analogues of 1-O-octadecyl-2-O-methyl-rac-glycerol-3-phosphocholine (ET-18-OMe), containing a carbonyl group at different positions in the alkyl chain and/or a pentylammonium group in sn-3 of glycerol, were evaluated as inhibitors of protein kinase C (PKC; EC 2.7.1.37). The presence of a carbonyl group in the alkyl chain of Et-18-OMe had a dual role in decreasing the inhibitory effect on histone phosphorylation and activating this reaction at low concentrations of compound. The optimal… CONTINUE READING